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[DOI] [PMC free article] [PubMed] [Google Scholar] 38.Brueckl W.M., Jung A., Wein A., Brabletz T., Guenther K., Nusko G., Hahn E.G

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In drug-resistant breast cancer cells, GPER stabilizes the expression of hypoxia-inducible factor 1 alpha (HIF-1), regulating the glycolytic metabolism of tumor cells and promoting metabolic reprogramming [230]

However, bromelain should be used with caution as it has a blood-thinning effect and delays clotting

Ethyl gallate, isolated from the natural plant, is a phenolic acid derivative